A.M. Folasire1, A.I. Michael2, A.A. Oladeji1, and G.O. Ogun3
- Department of Radio-Oncology, University College Hospital, Ibadan. Nigeria.
- Department of Plastic, Reconstructive and Aesthetic Surgery, University College Hospital, Ibadan. Nigeria
- Department of Pathology, University College Hospital, Ibadan, Nigeria.
Keywords: Non-bony metastasis, Hands, Cervical cancer
Dr. A.I. Michael
Department of Plastic Reconstructive
and Aesthetic Surgery
University College Hospital,
Ibadan, Oyo State,
Hand metastases from carcinomas are very rare and account for just 0.1% of all metastases1. When they occur, bony metastases are the typical presenting feature2. We report an extremely rare case of bilateral non-bony metastasis to the hand of an 85 year-old woman from cervical cancer.
An 85-year-old woman presented to us with nodular masses of various sizes on both palms and ulcerated bleeding nodule on her right thumb [Fig. 1]. Four months earlier she had been diagnosed with invasive squamous cell carcinoma of cervix. The histologic diagnosis of the cervical carcinoma was that of a poorly differentiated squamous cell carcinoma. A CT scan of the abdomen, showed multiple noncalcified nodules in the lung bases suggestive of pulmonary metastasis and mild right renal hydronephrosis making it a Stage IV disease.
She was treated with palliative external beam radiotherapy in a hospital in the United States of America. The patient was a known diabetic and hypertensive patient with no history of allergy, no recent additions to or changes in her medications and no pruritus. The remainder of her medical history was non-contributory.
Physical examination revealed multiple nodular lesions on the palms of both hands. They were more on the left palm and varied in size from 0.3cm to 1cm in diameter. The nodules were firm, tender and mobile. The nodule on the left thumb was ulcerated. The rest of the physical examination were unremarkable. A diagnosis of pyogenic granuloma of the left thumb and differential diagnosis of Dupuytrens nodules of the palm were made. Hematological investigations were normal. Chest X-ray and abdomino-pelvic – ultrasonography were unremarkable. She had excisional biopsies of the thumb and palmar lesions that revealed metastatic squamous cell carcinoma [Fig. 2]. She declined any further treatment and died four months after the diagnosis of the cutaneous metastasis to the palms.
Cutaneous metastases are seen in up to 10% of all malignancies4. Cancers with a predilection to metastasize to the skin are cancers from the breast, colorectum, melanoma, lung and oral cavity3-6. The occurrence of cutaneous metastases suggests advanced disease and is associated with a poor prognosis2-8. The clinical presentation however is variable and can mimic benign skin lesions2,7 as seen in our case. A high index of suspicion therefore is required for its recognition.
Hand metastasis from a primary internal malignancy is very rare, seen only in about 0.1% of metastases1. The metastatic lesions are found more commonly in the phalanges, metacarpal and carpal bones1,2,6. Cutaneous hand involvement is therefore extremely rare and the diagnosis can be missed particularly when it is the only presenting feature2,6. Subungal metastases have been reported in patients with primary internal malignancies arising from the lung, genitourinary system and the breast6.
Cutaneous metastases from cervical cancer are seen in less than 2% of patients and more commonly seen is metastasizes to the trunk, vulva and lower extremities9-11There has been only one previous report known to the authors of metastasis to the hand from cervical cancer by Elamurugen et al., in which they reported cervical cancer metastasis to the palm of one hand with frank features of a fungating lesion12. Bilateral non-bony metastasis to the hands as seen in our case has not as far as we are aware been previously reported. The multinodular features and squamous cell pathology seen in our patient are in keeping with the typical presenting features of metastatic lesions from cervical cancer9-11. Other morphological patterns seen in metastatic squamous cell carcinoma of the cervix could include, carcinoma en cuirrase, carcinoma telangiectaticum, Sister Mary Joseph’s nodule, alopecia neoplastica, and cicatricial and bullous forms10,11.