AIPMED

ANNALS OF IBADAN POSTGRADUATE MEDICINE

HISTOMORPHOLOGICAL PATTERN OF UROLOGIC MALIGNANCIES IN ILE-IFE, SOUTH-WESTERN NIGERIA

M.C Igbokwe1 , T.A Badmus1 , A.A Salako1 , A.O Komolafe2 , R.A David3 , O.Z Omoyiola2 , A Laoye3 , I.A Akinbola3 , C.I. Onyeze3 and R.N Babalola3 

  1. Department of Surgery, Obafemi Awolowo University, Ile-Ife/Urology Unit, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.
  2. Department of Histopathology and Forensic Medicine, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.
  3. Urology Unit, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.

ABSTRACT

Introduction: The last decade witnessed a remarkable rise in the prevalence of several malignant diseases in Nigeria. Whether Urologic malignancies (UM) have followed the same trend remains to be studied. The pattern of UM diagnosed in a Nigerian tertiary hospital is hereby presented. Our aim was to determine the pattern and prevalence of histologically diagnosed UM in Obafemi Awolowo University Teaching Hospitals Complex. Ile-Ife, Nigeria.

Materials and Methods: A 10-year retrospective review of all patients diagnosed with UM was carried out between January 2005 and December 2014. Data was obtained from the patients’ case files and the Ife-Ijesha Cancer registry. Information obtained included demographic characteristics, site of origin and histology. Data was analysed with Statistical package for Social sciences (SPSS) Version 20.

Results: A total of 4675 malignancies were histologically confirmed during the study period. UM accounted for 420 (8.9%) of total malignancies. Prostate cancer was the commonest UM with 315 (75%) cases. Others include renal tumours 62(14.8%), bladder tumours 29 (6.9%), testicular tumours 13(3.1%) and scrotal tumour 1(0.2%). UM were commoner in males (348, 88.8%) than females (47, 11.2%) and accounted for 13.8% and 2.18% of all tumours in males and females respectively.

Conclusion: This study revealed a rising prevalence of UM most especially Prostate and Renal Cancers among other malignancies in Ile-Ife.

Keywords: Pattern, Urologic malignancies, Ile-Ife.

Correspondence

Dr. M.C. Igbokwe

Department of Surgery,

Obafemi Awolowo University, Ile-Ife/

Urology Unit, Obafemi Awolowo University

Teaching Hospitals Complex, Ile-Ife,

Nigeria

Email:martini4life@yahoo.com


INTRODUCTION

Urologic malignancies (UM) are encountered worldwide with varying patterns and prevalence1 . UM are major causes of morbidity and mortality with a significant effect on age-adjusted life years in afflicted individuals2 . Technological advancement in diagnostic modalities, minimal access surgery and modern drugs have changed the face of diagnosis and treatment of UM2 . Nigeria, the most populous black nation in the world has witnessed an increasing burden of UM in the past decade especially Prostate cancer (PCa)3, 4 . Reports from tertiary centers in different geo-political zones of Nigeria have shown some epidemiological peculiarities in the pattern of UM with higher reports of bladder cancer in the Northern part of Nigeria5 . In the oil-rich Southern Nigeria, certain genetic predisposing factors and environmental exposure have been alluded to in the aetio-pathogenesis of some UM6, 7 . From previous studies, UM account for a significant burden of cancer patients in Nigeria. Prostate and bladder cancer have been shown to be the commonest malignancies across Nigeria in papers from South-south and North-western Nigeria respectively5, 8. There is however paucity of information on the recent pattern of UM in South-western Nigeria. This study aims to analyse the pattern of GUM diagnosed at the Ife-Ijesha cancer registry over a 10- year period.